Stromal Interaction Molecule 2 (Stim2) (Extracellular Domain), (AA 150-200) antibody

Details for Product No. ABIN350882
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Antigen
Synonyms STIM2
Epitope
Extracellular Domain, AA 150-200
(11), (9), (8), (5), (3), (2), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(42), (26), (24)
Host
Rabbit
(42), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(43), (30), (21), (14), (2)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350882
454.67 $
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Immunogen A synthetic peptide from aa region 150-200 of the extracellular domain of mouse STIM2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.
Specificity Specific for STIM2.
Purification Whole serum
Alternative Name STIM2
Background Function: Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx.
Subcellular location: Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane. Note: Translocates from the endoplasmic reticulum to punctual endoplasmic reticulum-cell plasma membrane junctions in response to decrease in endoplasmic reticulum Ca2+ concentration.
Tissue specificity: Expressed in all tissues and tumor cell lines examined. Also known as: STIM2.
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Williams, Manji, Parker et al.: "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins." in: The Biochemical journal, Vol. 357, Issue Pt 3, pp. 673-85, 2001 (PubMed).

Okazaki, F-Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 3, pp. 205-18, 2004 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Stathopulos, Zheng, Ikura: "Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics." in: The Journal of biological chemistry, Vol. 284, Issue 2, pp. 728-32, 2009 (PubMed).

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