SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody

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Antigen
  • CG4494
  • Dm0342
  • DmSUMO-1
  • DmSmt3
  • Dmel\\CG4494
  • Dmsmt3
  • SMT3
  • SUMO
  • Smt3
  • Sumo
  • anon-EST:Posey240
  • dSmt3
  • dsmt3
  • l(2)04493
  • l(2)SH0182
  • l(2)SH2 0182
  • sumo
  • SUMO1
  • sumo-1
  • sumo1
  • 4921531N22Rik
  • AI789753
  • AU040360
  • DAP-1
  • Gkap
  • DAP1
  • GMP1
  • OFC10
  • PIC1
  • SENP2
  • SMT3C
  • SMT3H3
  • UBL1
  • ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1
  • ATSUMO1
  • F10M23.180
  • F10M23_180
  • SMALL UBIQUITIN-LIKE MODIFIER 1
  • SUM1
  • SUMO 1
  • small ubiquitin-like modifier 1
  • pigSUMO1
  • SENTRIN
  • SMTP3
  • SUMO-1
  • Smt3C
  • Ubl1
  • hm:zeh0670
  • wu:fb74c02
  • wu:fd12c02
  • zgc:65934
  • zgc:85634
  • CG4494 gene product from transcript CG4494-RA
  • SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
  • small ubiquitin-related protein 1
  • smt3 suppressor of mif two 3 homolog 1
  • small ubiquitin-related modifier 1
  • death-associated protein
  • discs, large (Drosophila) homolog-associated protein 1
  • small ubiquitin-like modifier 1
  • SMT3 suppressor of mif two 3 homolog 1 (yeast)
  • smt3
  • SUMO1
  • sumo-1
  • sumo1
  • Dap
  • DAP
  • Dlgap1
  • Sumo1
Alternatives
anti-Human SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) antibody for Immunofluorescence (fixed cells)
Epitope
N-Term
44
16
15
14
13
7
7
6
5
4
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
336
149
108
9
8
7
7
6
5
3
3
2
2
1
1
1
1
1
Host
Rabbit
210
120
4
2
2
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
17
15
14
10
7
7
6
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
263
133
129
117
105
105
66
53
40
39
10
10
6
2
1
Options
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Immunogen A synthetic peptide from the n-terminal of rat SUMO 1 (SUMO-1, Small ubiquitin related modifier 1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human, mouse and chicken.
Specificity Specific for SUMO 1.
Purification Whole serum
Alternative Name SUMO 1 (SUMO1 Antibody Abstract)
Background Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4
Subcellular location: Nucleus. Cytoplasm Post-translational modification: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Also known as: Small ubiquitin-related modifier 1, SUMO-1, Sumo1.
Pathways M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
Application Notes A dilution of 1: 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Um, Chung: "Functional modulation of parkin through physical interaction with SUMO-1." in: Journal of neuroscience research, Vol. 84, Issue 7, pp. 1543-54, 2006 (PubMed).

Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Shao, Zhang, Tian, Anders Friberg, Wang, Sjoeland, Billig: "Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo." in: FEBS letters, Vol. 569, Issue 1-3, pp. 293-300, 2004 (PubMed).