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SUMO2 antibody (SMT3 Suppressor of Mif Two 3 Homolog 2 (S. Cerevisiae)) (N-Term)

Details for Product anti-SUMO2 Antibody No. ABIN350886, Supplier: Log in to see
Antigen
  • ATSUMO2
  • HSMT3
  • hsmt3
  • MCO15.11
  • MCO15_11
  • PSMT3
  • SMALL UBIQUITIN-LIKE MODIFIER 2
  • small ubiquitin-like modifier 2
  • SMT3A
  • Smt3A
  • SMT3B
  • Smt3B
  • Smt3b
  • smt3b
  • SMT3H1
  • Smt3h2
  • SMT3H2
  • smt3h2
  • SUM2
  • SUMO-2
  • sumo-2
  • SUMO-3
  • SUMO2
  • sumo2
  • SUMO 2
  • SUMO3
  • zgc:92241
Epitope
N-Term
46
33
10
10
7
7
5
5
4
3
2
2
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
150
28
21
12
2
1
1
1
1
Host
Rabbit
134
27
1
Clonality
Polyclonal
Conjugate
This SUMO2 antibody is un-conjugated
10
9
9
9
9
9
Application
Immunohistochemistry (IHC), Western Blotting (WB)
121
101
47
24
20
6
5
3
2
1
1
Supplier
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Immunogen A synthetic peptide from the n-terminal of rat SUMO2 & SUMO3 (Small ubiquitin-related modifier 2 and 3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including human, mouse and chicken.
Isotype IgG
Specificity Specific for SUMO2 and SUMO3.
Alternative Name SUMO 2 (SUMO2 Antibody Abstract)
Background Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4
Subcellular location: Nucleus Also known as: Small ubiquitin-related modifier 2, SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin-2, Smt3b, Smt3h2, SUMO-3, SUMO 3, Small ubiquitin-related modifier 3.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Zody, Garber, Adams, Sharpe, Harrow, Lupski, Nicholson, Searle, Wilming, Young, Abouelleil, Allen, Bi, Bloom, Borowsky, Bugalter, Butler, Chang, Chen, Cook, Corum, Cuomo, de Jong, DeCaprio, Dewar et al.: "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. ..." in: Nature, Vol. 440, Issue 7087, pp. 1045-9, 2006

Baba, Maita, Jee, Uchimura, Saitoh, Sugasawa, Hanaoka, Tochio, Hiroaki, Shirakawa: "Crystal structure of SUMO-3-modified thymine-DNA glycosylase." in: Journal of molecular biology, Vol. 359, Issue 1, pp. 137-47, 2006

Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5308-13, 2006

Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005

Chen, Mannen, Li: "Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes." in: Biochemistry and molecular biology international, Vol. 46, Issue 6, pp. 1161-74, 1999