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Details for Product No. ABIN350903

Synaptosomal-Associated Protein, 25kDa (SNAP25) antibody

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Antigen
Synonyms RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2, sp, Bdr, SNAP-25B, SNAP-25a, ric-4, ric4, sec9, snap-25
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN350903
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from mouse Synaptosomal associated protein 25 (SNAP-25, SNAP25, SEC9, RIC-4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.
Isotype IgG
Specificity Appears to be specific for SNAP-25.
Purity IgG
Alternative Name Synaptosomal associated protein 25 (SNAP-25,SNAP25, SEC9, RIC-4)
Background Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
Subunit: Part of the SNARE core complex containingSNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1,SNAP25BP and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1.
Subcellular location: Membrane, Lipid-anchor. Cell junction, synapse, synaptosome. Note: Membrane association requires palmitoylation.
Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum. Also known as:SNAP-25, Synaptosomal-associated 25 kDa protein,SNAP25, RIC4, SEC9,SNAP, RIC-4, Super protein, SUP.
UniProt P60881
Application Notes IHC, WB. A working concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Hess, Slater, Wilson et al.: "The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 12, Issue 12, pp. 4634-41, 1993 (PubMed).

Jacobsson, Piehl, Bark et al.: "Differential subcellular localization of SNAP-25a and SNAP-25b RNA transcripts in spinal motoneurons and plasticity in expression after nerve injury." in: Brain research. Molecular brain research, Vol. 37, Issue 1-2, pp. 49-62, 1996 (PubMed).

Bean, Seifert, Chen et al.: "Hrs-2 is an ATPase implicated in calcium-regulated secretion." in: Nature, Vol. 385, Issue 6619, pp. 826-9, 1997 (PubMed).

Sutton, Fasshauer, Jahn et al.: "Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution." in: Nature, Vol. 395, Issue 6700, pp. 347-53, 1998 (PubMed).

Madison, Krueger, Cheng et al.: "SNARE complex proteins, including the cognate pair VAMP-2 and syntaxin-4, are expressed in cultured oligodendrocytes." in: Journal of neurochemistry, Vol. 72, Issue 3, pp. 988-98, 1999 (PubMed).

Fasshauer, Antonin, Margittai et al.: "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15440-6, 1999 (PubMed).

Coppola, Magnin-Luthi, Perret-Menoud et al.: "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 32756-62, 2001 (PubMed).

Scales, Hesser, Masuda et al.: "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28271-9, 2002 (PubMed).

Hepp, Cabaniols, Roche: "Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A." in: FEBS letters, Vol. 532, Issue 1-2, pp. 52-6, 2002 (PubMed).

Ernst, Brunger: "High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8630-6, 2003 (PubMed).

Alternatives for antigen "Synaptosomal-Associated Protein, 25kDa (SNAP25)", type "Antibodies"
Hosts (84), (79), (10), (7), (1)
Reactivities (143), (77), (64), (24), (24), (11), (10), (9), (6), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (146), (77), (46), (36), (20), (15), (11), (11), (10), (10), (6), (4), (3), (2), (2)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (30), (9), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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