Synaptotagmin I (SYT1) antibody

Details for Product No. ABIN350921
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Antigen
Synonyms
P65, SVP65, SYT, AW124717, G630098F17Rik, SytI, CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Dmel\\CG3139, Droso1, Dsyt2, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, ... show more
P65, SVP65, SYT, AW124717, G630098F17Rik, SytI, CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Dmel\\CG3139, Droso1, Dsyt2, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, syt, syt 1, syt I, syt-1, syt1, sytI, Syti, GB20036, svp65, DKFZP459P193, p65 show less
Reactivity
Human
(118), (95), (80), (45), (42), (41), (36), (3), (2), (2), (1)
Host
Rabbit
(112), (25), (6), (5), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(109), (37), (37), (30), (22), (21), (19), (9), (1)
Pubmed 1 reference available
Catalog no. ABIN350921
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide as a part of human Synaptotagmin-1 (Synaptotagmin I, SytI, p65, SVP65) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for Cystatin-8.
Purification whole serum
Alternative Name Synaptotagmin-1 (Synaptotagmin I, SytI, p65, SVP65)
Background Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner, these are neurexins, syntaxin and AP2.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules.
Tissue specificity: Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. Also known as: Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65.
UniProt O60676
Application Notes A dilution of 1 : 300 to 1 : 5000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Perin, Fried, Mignery et al.: "Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C." in: Nature, Vol. 345, Issue 6272, pp. 260-3, 1990 (PubMed).

Hosts (112), (25), (6), (5), (3), (2)
Reactivities (118), (95), (80), (45), (42), (41), (36), (3), (2), (2), (1)
Applications (109), (37), (37), (30), (22), (21), (19), (9), (1)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (25), (17), (9), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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