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Details for Product No. ABIN350925

Synaptotagmin I (SYT1) antibody

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Antigen
Synonyms
P65, SVP65, SYT, AW124717, G630098F17Rik, SytI, CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, Dmel\\CG3139, Droso1, Dsyt2, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN350925
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human Synaptotagmin-1 (Synaptotagmin I, SytI, p65, SVP65) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for SYTI.
Purity IgG
Alternative Name Synaptotagmin-1 (Synaptotagmin I, SytI, p65, SVP65)
Background Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner, these are neurexins, syntaxin and AP2.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules.
Tissue specificity: Predominantly expressed in rostral, phylogenetically younger brain regions, and in some endocrine tissues. Also known as: Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65.
UniProt P21579
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Perin, Fried, Mignery et al.: "Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C." in: Nature, Vol. 345, Issue 6272, pp. 260-3, 1990 (PubMed).

Alternatives for antigen "Synaptotagmin I (SYT1)", type "Antibodies"
Hosts (96), (20), (5), (4), (3), (2)
Reactivities (107), (85), (79), (43), (42), (40), (36), (3), (3), (2), (1)
Applications (88), (32), (31), (30), (22), (21), (14), (8), (3)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (24), (17), (7), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1)
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