Synaptotagmin II (SYT2) antibody

Antigen: Synaptotagmin II (SYT2)

Synonyms: SytII, FLJ42519, R74640, KIAA4194, mKIAA4194, SYNII, RATSYNII, si:ch211-236j4.1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350926

Additional Information

Alternative name: Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2)

Swiss-Prot: Q8N9I0

Immunogen: A synthetic peptide as a part of human Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains. SUBUNIT: Homotetramer. Interacts with stonin 2. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules. Also known as: Synaptotagmin II, SytII, SYT2.

Specificity: Appears to be specific for SYTII.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).