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Synaptotagmin II (SYT2) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350927
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Antigen
Synonyms SytII, R74640, mKIAA4194, SYNII, RATSYNII, si:ch211-236j4.1
Epitope
Cytoplasmic Domain
(10), (7), (6), (6), (5), (4), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(52), (28), (27), (13), (12), (12), (12)
Host
Goat
(43), (11), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(39), (21), (10), (10), (5), (5), (4), (3)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN350927
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the cytoplasmic domain of rat Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SYT17.
Purification whole serum
Alternative Name Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2)
Background Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subunit: Homotetramer. Interacts with stonin 2.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules. Also known as: Synaptotagmin II, SytII, SYT2.
UniProt Q920M7
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
Supplier Images
anti-Synaptotagmin II (SYT2) (Cytoplasmic Domain) antibody IF on 1 day- old mouse cortical cell culture using Rabbit antibody to rat, mouse Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2): whole serum (ABIN350927) at 1: 2000 dilution. DAPI counter stained.
anti-Synaptotagmin II (SYT2) (Cytoplasmic Domain) antibody (2) IHC on rat spinal cord using Rabbit antibody to rat, mouse Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2): whole serum (ABIN350927) at 1 : 3000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).
anti-Synaptotagmin II (SYT2) (Cytoplasmic Domain) antibody (3) IHC on rat spinal cord using Rabbit antibody to rat, mouse Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2): whole serum (ABIN350927) at 1 : 3000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).
General Geppert, Archer, Südhof: "Synaptotagmin II. A novel differentially distributed form of synaptotagmin." in: The Journal of biological chemistry, Vol. 266, Issue 21, pp. 13548-52, 1991 (PubMed).

Fukuda, Aruga, Niinobe et al.: "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II." in: The Journal of biological chemistry, Vol. 269, Issue 46, pp. 29206-11, 1994 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350927
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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