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Details for Product No. ABIN350927

Synaptotagmin II (SYT2) (Cytoplasmic Domain) antibody

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Antigen
Synonyms SytII, R74640, mKIAA4194, SYNII, RATSYNII, si:ch211-236j4.1
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350927
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of rat Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SYT17.
Purity whole serum
Alternative Name Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2)
Background Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subunit: Homotetramer. Interacts with stonin 2.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules. Also known as: Synaptotagmin II, SytII, SYT2.
UniProt Q920M7
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Geppert, Archer, Südhof: "Synaptotagmin II. A novel differentially distributed form of synaptotagmin." in: The Journal of biological chemistry, Vol. 266, Issue 21, pp. 13548-52, 1991 (PubMed).

Fukuda, Aruga, Niinobe et al.: "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II." in: The Journal of biological chemistry, Vol. 269, Issue 46, pp. 29206-11, 1994 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Alternatives for antigen "Synaptotagmin II (SYT2)", type "Antibodies"
Hosts (38), (5), (3), (2)
Reactivities (42), (27), (26), (13), (12), (12), (12), (1), (1), (1), (1)
Applications (28), (11), (10), (10), (5), (5), (5), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1)
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