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Synaptotagmin V (SYT5) antibody

Details for Product No. ABIN350928, Supplier: Log in to see
Antigen
  • CG13462
  • CG3020
  • CG42333
  • Dmel\\CG42333
  • Dmel_CG13462
  • Dmel_CG3020
  • Syt V
  • Syt beta
  • Syt13
  • SytV
  • dsytbeta
  • syt13
  • sytbeta
  • syt5
  • zgc:92682
  • ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E
  • ATSYTE
  • NTMC2TYPE2.1
  • SYNAPTOTAGMIN HOMOLOG E
  • SYT5
  • SYTE
  • T25N20.15
  • synaptotagmin 5
  • Sytv
  • SytIX
Reactivity
Mouse (Murine)
37
6
4
2
2
2
1
Host
Rabbit
26
11
2
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
35
26
4
1
1
Supplier
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Immunogen A synthetic peptide from mouse Synaptotagmin-5 (Synaptotagmin V, SytV, Synaptotagmin IX, Syt5) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SYT5.
Purification Whole serum
Alternative Name Synaptotagmin 5 (SYT5 Antibody Abstract)
Background Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subunit: Homodimer. Can also form heterodimers. Interacts with both alpha- and beta-tubulin.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Multi-pass membrane protein. Recycling endosome membrane, Multi-pass membrane protein. Note: In mast cells, localizes to the endocytic recycling compartment. Also known as: Synaptotagmin 5, Synaptotagmin V, SytV, Synaptotagmin IX, Syt5.
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
 image for anti-Synaptotagmin V (SYT5) antibody (ABIN350928) IF on 1 day- old mouse cortical cell culture using Rabbit antibody to rat, mouse Syna...
Background publications Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Haberman, Grimberg, Fukuda et al.: "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules." in: Journal of cell science, Vol. 116, Issue Pt 21, pp. 4307-18, 2003 (PubMed).

Fukuda, Kowalchyk, Zhang et al.: "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4601-4, 2002 (PubMed).

Fukuda, Kanno, Mikoshiba: "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31421-7, 1999 (PubMed).

Craxton, Goedert: "Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain." in: FEBS letters, Vol. 361, Issue 2-3, pp. 196-200, 1995 (PubMed).

Hudson, Birnbaum: "Identification of a nonneuronal isoform of synaptotagmin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 13, pp. 5895-9, 1995 (PubMed).