Synaptotagmin V (SYT5) antibody

Details for Product No. ABIN350928
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Antigen
Synonyms
CG13462, CG3020, CG42333, Dmel\\CG42333, Dmel_CG13462, Dmel_CG3020, Syt V, Syt beta, Syt13, SytV, dsytbeta, syt13, sytbeta, syt5, zgc:92682, ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E, ATSYTE, NTMC2 ... show more
CG13462, CG3020, CG42333, Dmel\\CG42333, Dmel_CG13462, Dmel_CG3020, Syt V, Syt beta, Syt13, SytV, dsytbeta, syt13, sytbeta, syt5, zgc:92682, ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E, ATSYTE, NTMC2TYPE2.1, SYNAPTOTAGMIN HOMOLOG E, SYT5, SYTE, T25N20.15, synaptotagmin 5, Sytv, SytIX show less
Reactivity
Tag
(28), (13), (13), (13), (13), (12), (12), (1)
Host
Rabbit
(26), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(19), (10), (7), (3), (2), (1)
Pubmed 6 references available
Quantity 100 µL
Options
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Catalog No. ABIN350928
454.67 $
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Immunogen A synthetic peptide from mouse Synaptotagmin-5 (Synaptotagmin V, SytV, Synaptotagmin IX, Syt5) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SYT5.
Purification Whole serum
Alternative Name Synaptotagmin 5
Background Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subunit: Homodimer. Can also form heterodimers. Interacts with both alpha- and beta-tubulin.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Multi-pass membrane protein. Recycling endosome membrane, Multi-pass membrane protein. Note: In mast cells, localizes to the endocytic recycling compartment. Also known as: Synaptotagmin 5, Synaptotagmin V, SytV, Synaptotagmin IX, Syt5.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
anti-Synaptotagmin V (SYT5) antibody IF on 1 day- old mouse cortical cell culture using Rabbit antibody to rat, mouse Synaptotagmin-5 (Synaptotagmin V, SytV, Synaptotagmin IX, Syt5): whole serum (ABIN350928) at 1: 2000 dilution. DAPI counter stained.
General Hudson, Birnbaum: "Identification of a nonneuronal isoform of synaptotagmin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 13, pp. 5895-9, 1995 (PubMed).

Craxton, Goedert: "Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain." in: FEBS letters, Vol. 361, Issue 2-3, pp. 196-200, 1995 (PubMed).

Fukuda, Kanno, Mikoshiba: "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31421-7, 1999 (PubMed).

Fukuda, Kowalchyk, Zhang et al.: "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4601-4, 2002 (PubMed).

Haberman, Grimberg, Fukuda et al.: "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules." in: Journal of cell science, Vol. 116, Issue Pt 21, pp. 4307-18, 2003 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Validation Images
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