Syntaxin 16 (STX16) antibody

Antigen: Syntaxin 16 (STX16)

Synonyms: SYN16, hsyn16, MGC90328, CG1467, Dm Syx16, DmelCG1467, DmSyx16, dSyx 16, dSyx16, Syx, SYX16, Syn16, AI648908, AW553605, 4930401D03, 5430410K23Rik, 6330500A18Rik, stx16a, MGC83676, STX16, im:7158627, syn16, ACYPI005518, DKFZp459J1550

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN350934

Additional Information

Alternative name: Syntaxin-16 (Syntaxin 16, STX16, Syn16)

UniProt: Q8BVI5

Immunogen: A synthetic peptide from mouse Syntaxin-16 (Syntaxin 16, STX16, Syn16) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in chicken, orangutan and pig.

Format: Lyophilized

Description: FUNCTION: SNARE involved in a vesicular transport step within the Golgi stack. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein. SUBCELLULAR LOCATION: Isoform C: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Also known as: Syntaxin 16, STX16, Syn16.

Specificity: Appears to be specific for Syntaxin-16.

Synonyms: SYN16, hsyn16, MGC90328, CG1467, Dm Syx16, DmelCG1467, DmSyx16, dSyx 16, dSyx16, Syx, SYX16, Syn16, AI648908, AW553605, 4930401D03, 5430410K23Rik, 6330500A18Rik, stx16a, MGC83676, STX16, im:7158627, syn16, ACYPI005518, DKFZp459J1550

Application Details

Application Notes: IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Images

IF on 1 day- old mouse cortical cell culture using Rabbit antibody to mouse, chicken, orangutan, pig Syntaxin-16 (Syntaxin 16, STX16, Syn16): whole serum (ABIN350934) at 1: 2000 dilution.

IHC on rat brain (striatum) using Rabbit antibody to mouse, chicken, orangutan, pig Syntaxin-16 (Syntaxin 16, STX16, Syn16): whole serum (ABIN350934) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IF on 1 day- old mouse cortical cell culture using Rabbit antibody to mouse, chicken, orangutan, pig Syntaxin-16 (Syntaxin 16, STX16, Syn16): whole serum (ABIN350934) at 1: 2000 dilution.

Publications

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).