Syntaxin 16 (STX16) (AA 100-200) antibody

Details for Product No. ABIN350935
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Antigen
Synonyms
CG1467, Dm Syx16, DmSyx16, Dmel\\CG1467, SYX16, Syx, dSyx 16, dSyx16, syntaxin-16, stx16, stx16a, syn16, STX16, im:7158627, ACYPI005518, 4930401D03, 5430410K23Rik, 6330500A18Rik, AI648908, AW553605, S ... show more
CG1467, Dm Syx16, DmSyx16, Dmel\\CG1467, SYX16, Syx, dSyx 16, dSyx16, syntaxin-16, stx16, stx16a, syn16, STX16, im:7158627, ACYPI005518, 4930401D03, 5430410K23Rik, 6330500A18Rik, AI648908, AW553605, Syn16, SYN16 show less
Epitope
AA 100-200
(11), (8), (3), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(21), (5), (5), (2)
Host
Rabbit
(19), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(22), (13), (9), (5), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 100 μL
Options
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Catalog No. ABIN350935
454.67 $
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Immunogen A synthetic peptide from aa region 100-200 of human Syntaxin-16 (Syntaxin 16, STX16, Syn16) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Syntaxin-16.
Purification Whole serum
Alternative Name Syntaxin 16
Background Function: SNARE involved in a vesicular transport step within the Golgi stack.
Subcellular location: Golgi apparatus membrane, Single-pass type IV membrane protein.
Subcellular location: Isoform C: Cytoplasm.
Tissue specificity: Ubiquitous. DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Also known as: Syntaxin 16, STX16, Syn16.
Research Area Organelles
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Tang, Low, Lee et al.: "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins." in: Biochemical and biophysical research communications, Vol. 242, Issue 3, pp. 673-9, 1998 (PubMed).

Simonsen, Bremnes, Ruonning et al.: "Syntaxin-16, a putative Golgi t-SNARE." in: European journal of cell biology, Vol. 75, Issue 3, pp. 223-31, 1998 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Bastepe, Froehlich, Hendy et al.: "Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS." in: The Journal of clinical investigation, Vol. 112, Issue 8, pp. 1255-63, 2003 (PubMed).

Linglart, Gensure, Olney et al.: "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS." in: American journal of human genetics, Vol. 76, Issue 5, pp. 804-14, 2005 (PubMed).

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