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Syntaxin 16 (STX16) (AA 100-200) antibody

Details for Product No. ABIN350935, Supplier: Log in to see
Antigen
  • CG1467
  • Dm Syx16
  • DmSyx16
  • Dmel\\CG1467
  • SYX16
  • Syx
  • dSyx 16
  • dSyx16
  • syntaxin-16
  • stx16
  • stx16a
  • syn16
  • STX16
  • im:7158627
  • ACYPI005518
  • 4930401D03
  • 5430410K23Rik
  • 6330500A18Rik
  • AI648908
  • AW553605
  • Syn16
  • SYN16
Epitope
AA 100-200
20
16
3
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
39
11
8
2
Host
Rabbit
34
5
2
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
36
25
16
7
2
1
1
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Immunogen A synthetic peptide from aa region 100-200 of human Syntaxin-16 (Syntaxin 16, STX16, Syn16) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Syntaxin-16.
Purification Whole serum
Alternative Name Syntaxin 16 (STX16 Antibody Abstract)
Background Function: SNARE involved in a vesicular transport step within the Golgi stack.
Subcellular location: Golgi apparatus membrane, Single-pass type IV membrane protein.
Subcellular location: Isoform C: Cytoplasm.
Tissue specificity: Ubiquitous. DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Also known as: Syntaxin 16, STX16, Syn16.
Research Area Organelles
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Linglart, Gensure, Olney et al.: "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS." in: American journal of human genetics, Vol. 76, Issue 5, pp. 804-14, 2005 (PubMed).

Bastepe, Froehlich, Hendy et al.: "Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS." in: The Journal of clinical investigation, Vol. 112, Issue 8, pp. 1255-63, 2003 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Simonsen, Bremnes, Ruonning et al.: "Syntaxin-16, a putative Golgi t-SNARE." in: European journal of cell biology, Vol. 75, Issue 3, pp. 223-31, 1998 (PubMed).

Tang, Low, Lee et al.: "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins." in: Biochemical and biophysical research communications, Vol. 242, Issue 3, pp. 673-9, 1998 (PubMed).