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Details for Product No. ABIN350936

Syntaxin 1A (Brain) (STX1A) antibody

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HPC-1, P35-1, STX1, SYN1A, CG10716, CG18615, CG31136, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\\CG31136, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, l(3)06 ... show more
»Alternatives Rat (Rattus), Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 9 references available
Catalog no. ABIN350936
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of rat, mouse Syntaxin-1A (Syntaxin 1A, STX1A, P35A, Sap) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for Syntaxin-1A.
Purity whole serum
Alternative Name Syntaxin-1A (Syntaxin 1A, STX1A)
Background Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.
Subunit: Interacts with SYTL4, VAPA and SYBU. Found in a complex with VAMP8 andSNAP23. Part of the SNARE core complex containingSNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds STXBP6. Found in a ternary complex with STX1A andSNAP25.
Subcellular location: Membrane, Single-pass type IV membrane protein.
Tissue specificity: Expressed predominantly in cerebral cortex, hippocampus, cerebellum, adrenal medulla and retina with weak expression detected in non-neuronal tissues. Also known as: Syntaxin-1A, Synaptotagmin-associated 35 kDa protein, P35A, Neuron-specific antigen HPC-1, Sap, Syntaxin 1A.
UniProt P32851
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Yoshida, Oho, Omori et al.: "HPC-1 is associated with synaptotagmin and omega-conotoxin receptor." in: The Journal of biological chemistry, Vol. 267, Issue 35, pp. 24925-8, 1993 (PubMed).

Inoue, Obata, Akagawa: "Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1." in: The Journal of biological chemistry, Vol. 267, Issue 15, pp. 10613-9, 1992 (PubMed).

Bennett, García-Arrarás, Elferink et al.: "The syntaxin family of vesicular transport receptors." in: Cell, Vol. 74, Issue 5, pp. 863-73, 1993 (PubMed).

Sutton, Fasshauer, Jahn et al.: "Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution." in: Nature, Vol. 395, Issue 6700, pp. 347-53, 1998 (PubMed).

Fasshauer, Antonin, Margittai et al.: "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15440-6, 1999 (PubMed).

Misura, Scheller, Weis: "Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex." in: Nature, Vol. 404, Issue 6776, pp. 355-62, 2000 (PubMed).

Lerman, Robblee, Fairman et al.: "Structural analysis of the neuronal SNARE protein syntaxin-1A." in: Biochemistry, Vol. 39, Issue 29, pp. 8470-9, 2000 (PubMed).

Scales, Hesser, Masuda et al.: "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28271-9, 2002 (PubMed).

Ernst, Brunger: "High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8630-6, 2003 (PubMed).

Alternatives for antigen "Syntaxin 1A (Brain) (STX1A)", type "Antibodies"
Hosts (84), (22), (1)
Reactivities (94), (63), (62), (38), (38), (24), (12), (12), (5), (1), (1), (1)
Applications (60), (35), (31), (30), (13), (12), (6), (4), (4), (3), (3), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (18), (17), (12), (7), (2), (2), (2), (1)