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Syntaxin 1A (Brain) (STX1A) antibody

Details for Product No. ABIN350936
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Antigen
Synonyms
HPC-1, P35-1, STX1, SYN1A, CG10716, CG18615, CG31136, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\\CG31136, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, l(3)06 ... show more
HPC-1, P35-1, STX1, SYN1A, CG10716, CG18615, CG31136, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\\CG31136, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, l(3)06737, synt, syt-1A, syx, syx-1, syx-1A, syx1, syx1A, STX1A, hpc-1, p35-1, stx1, sx1a, syntaxin1a show less
Reactivity
Rat (Rattus), Mouse (Murine)
(118), (68), (67), (38), (37), (24), (12), (12), (4), (1), (1), (1)
Host
Sheep
(103), (26)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(79), (44), (36), (30), (20), (18), (11), (10), (7), (4), (2)
Pubmed 9 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350936
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from mouse Syntaxin-1A conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for contactin-2.
Purification whole serum
Alternative Name Syntaxin-1A (Syntaxin 1A, STX1A)
Background Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.
Subunit: Interacts with SYTL4, VAPA and SYBU. Found in a complex with VAMP8 andSNAP23. Part of the SNARE core complex containingSNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds STXBP6. Found in a ternary complex with STX1A andSNAP25.
Subcellular location: Membrane, Single-pass type IV membrane protein.
Tissue specificity: Expressed predominantly in cerebral cortex, hippocampus, cerebellum, adrenal medulla and retina with weak expression detected in non-neuronal tissues. Also known as: Syntaxin-1A, Synaptotagmin-associated 35 kDa protein, P35A, Neuron-specific antigen HPC-1, Sap, Syntaxin 1A.
UniProt Q61330
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Yoshida, Oho, Omori et al.: "HPC-1 is associated with synaptotagmin and omega-conotoxin receptor." in: The Journal of biological chemistry, Vol. 267, Issue 35, pp. 24925-8, 1993 (PubMed).

Inoue, Obata, Akagawa: "Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1." in: The Journal of biological chemistry, Vol. 267, Issue 15, pp. 10613-9, 1992 (PubMed).

Bennett, García-Arrarás, Elferink et al.: "The syntaxin family of vesicular transport receptors." in: Cell, Vol. 74, Issue 5, pp. 863-73, 1993 (PubMed).

Sutton, Fasshauer, Jahn et al.: "Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution." in: Nature, Vol. 395, Issue 6700, pp. 347-53, 1998 (PubMed).

Fasshauer, Antonin, Margittai et al.: "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15440-6, 1999 (PubMed).

Misura, Scheller, Weis: "Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex." in: Nature, Vol. 404, Issue 6776, pp. 355-62, 2000 (PubMed).

Lerman, Robblee, Fairman et al.: "Structural analysis of the neuronal SNARE protein syntaxin-1A." in: Biochemistry, Vol. 39, Issue 29, pp. 8470-9, 2000 (PubMed).

Scales, Hesser, Masuda et al.: "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28271-9, 2002 (PubMed).

Ernst, Brunger: "High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8630-6, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350936
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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