Syntaxin 7 (STX7) antibody

Antigen: Syntaxin 7 (STX7)

Synonyms: Avl, Dm Syx7, DmSyx7, SYX7, Syx, DmelCG5081, CG5081, Syn7, AI315064, AI317144, AW107239, STX7, F27G20.2, SYNTAXIN 24, SYP24, Syntaxin-7, DKFZp459F1627

Clonality: Polyclonal

Host: Sheep

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350940

Additional Information

Alternative name: Syntaxin-7 (STX7, Syn7,Syntaxin 7)

UniProt: O70257

Immunogen: A synthetic peptide as a part of rat, mouse Syntaxin-7 (STX7, Syn7, Syntaxin 7) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. SUBUNIT: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Interacts with VPS33A. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B. Interacts with VPS11, VPS16 and VPS18. SUBCELLULAR LOCATION: Early endosome membrane; Single-pass type IV membrane protein. Also known as: Syntaxin-7, STX7, Syn7.

Specificity: Appears to be specific for Syntaxin-7.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Wong, Xu, Zhang et al.: "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 375-80, 1998 (PubMed).

Antonin, Holroyd, Fasshauer et al.: "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function." in: The EMBO journal, Vol. 19, Issue 23, pp. 6453-64, 2000 (PubMed).

Antonin, Fasshauer, Becker et al.: "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs." in: Nature structural biology, Vol. 9, Issue 2, pp. 107-11, 2002 (PubMed).

Pryor, Mullock, Bright et al.: "Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events." in: EMBO reports, Vol. 5, Issue 6, pp. 590-5, 2004 (PubMed).

Ballif, Villén, Beausoleil et al.: "Phosphoproteomic analysis of the developing mouse brain." in: Molecular & cellular proteomics : MCP, Vol. 3, Issue 11, pp. 1093-101, 2004 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).