Syntaxin 7 (STX7) antibody

Antigen: Syntaxin 7 (STX7)

Synonyms: Avl, Dm Syx7, DmSyx7, SYX7, Syx, DmelCG5081, CG5081, Syn7, AI315064, AI317144, AW107239, STX7, F27G20.2, SYNTAXIN 24, SYP24, Syntaxin-7, DKFZp459F1627

Clonality: Polyclonal

Host: Sheep

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350942

Additional Information

Alternative name: Syntaxin-7 (STX7, Syn7,Syntaxin 7)

UniProt: O15400

Immunogen: A synthetic peptide as a part of human Syntaxin-7 (STX7, Syn7, Syntaxin 7) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. SUBUNIT: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Interacts with VPS33A. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B. Interacts with VPS11, VPS16 and VPS18. SUBCELLULAR LOCATION: Early endosome membrane; Single-pass type IV membrane protein. Also known as: Syntaxin-7, STX7, Syn7.

Specificity: Appears to be specific for Syntaxin-7.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 5000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Wang, Frelin, Pevsner: "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes." in: Gene, Vol. 199, Issue 1-2, pp. 39-48, 1997 (PubMed).

Prekeris, Yang, Oorschot et al.: "Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking." in: Molecular biology of the cell, Vol. 10, Issue 11, pp. 3891-908, 1999 (PubMed).

Nakamura, Yamamoto, Wada et al.: "Syntaxin 7 mediates endocytic trafficking to late endosomes." in: The Journal of biological chemistry, Vol. 275, Issue 9, pp. 6523-9, 2000 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).