Syntaxin Binding Protein 1 (STXBP1) (Internal Region) antibody

Details for Product No. ABIN350945
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Antigen
Synonyms
MUNC18-1, NSEC1, P67, RBSEC1, UNC18, Ms10g, nsec1, N-sec1, Sxtbp1, Unc18h, MMS10-G, Rb-sec1, Unc18-1, AI317162, AI326233, Munc-18a, Munc18-1, stxbp1, MGC88906, fj43h10, wu:fj36d12, wu:fj43h10, zgc:114 ... show more
MUNC18-1, NSEC1, P67, RBSEC1, UNC18, Ms10g, nsec1, N-sec1, Sxtbp1, Unc18h, MMS10-G, Rb-sec1, Unc18-1, AI317162, AI326233, Munc-18a, Munc18-1, stxbp1, MGC88906, fj43h10, wu:fj36d12, wu:fj43h10, zgc:114171, rop, unc18, hunc18, rbsec1, munc18-1, MGC146482 show less
Epitope
Internal Region
(20), (8), (7), (5), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(74), (57), (56), (17), (16), (12), (7), (5), (1), (1)
Host
Rabbit
(67), (8), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (39), (20), (17), (15), (8), (3), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN350945
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal part of human Syntaxin-binding protein 1 (STXB1, p67, N-Sec1, Unc-18A, Unc-18-1, rbSec1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, mouse, chicken and monke
Specificity Specific for DRAM.
Purification IgG
Alternative Name Syntaxin-Binding Protein 1 (STXB1, Unc-18A)
Background Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Also known as: STXB1, p67, N-Sec1, Unc-18A, Unc-18-1, rbSec1.
UniProt Q8N682
Research Area Cancer, Autophagy, Cell Cycle, Apoptosis/Necrosis
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Gengyo-Ando, Kitayama, Mukaida et al.: "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 21, pp. 6695-702, 1996 (PubMed).

Gotoh, Yokota, Kikuya et al.: "Genomic structure of MUNC18-1 protein, which is involved in docking and fusion of synaptic vesicles in brain." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21642-7, 1998 (PubMed).

Collins, Yu, Coba et al.: "Proteomic analysis of in vivo phosphorylated synaptic proteins." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5972-82, 2005 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Hosts (67), (8), (7)
Reactivities (74), (57), (56), (17), (16), (12), (7), (5), (1), (1)
Applications (56), (39), (20), (17), (15), (8), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (20), (8), (7), (5), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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