Syntaxin Binding Protein 6 (STXBP6) antibody

Antigen: Syntaxin Binding Protein 6 (STXBP6)

Synonyms: LGL3, LLGL3, FLJ30922, MGC141942, MGC141968, Nbla04300, amisyn, HSPC156, FLJ39638, C85317, BC024598, MGC30948, Amisyn, MGC68796, zgc:86678, wu:fd20e06, hspc156, MGC88977, STXBP6, LOC100226852

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350946

Additional Information

Alternative name: Syntaxin-binding protein 5 (STXB5, Tomosyn-1, Llgl3)

Swiss-Prot: Q5T5C0

Immunogen: A synthetic peptide as a part of human Syntaxin-binding protein 5 (STXB5, Tomosyn-1, Llgl3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. SUBUNIT: Part of a complex that contains STXBP5, STX4A andSNAP23. Interacts with STX1A and STX4A via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5,SNAP25 and SYT1. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles. TISSUE SPECIFICITY: Isoform 1 is detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is detected in brain and in testis. Isoform 3 is detected in testis. Also known as: Lethal(2) giant larvae protein homolog 3, STXB5, Tomosyn-1, Llgl3.

Specificity: Appears to be specific for Syntaxin-binding protein 5.

Application Details

Application Notes: IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Zahedi, Lewandrowski, Wiesner et al.: "Phosphoproteome of resting human platelets." in: Journal of proteome research, Vol. 7, Issue 2, pp. 526-34, 2008 (PubMed).