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Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 330-380) antibody

Details for Product No. ABIN350951
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Antigen
Synonyms GPR70, T1R1, TR1, Gpr70, T1r1
Epitope
AA 330-380
(8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(40), (21), (20), (2)
Host
Rabbit
(46), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (14), (11), (10), (7), (4), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN350951
454.67 $
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Immunogen A synthetic peptide from aa region 330-380 of human TAS1R1 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TAS1R1.
Purification Whole serum
Alternative Name TAS1R1
Background The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene.
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms heterodimers with TAS1R3.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Taste receptor type 1 member 1 (precursor), G-protein, coupled receptor 70, TAS1R1, GPR70, T1R1, TR1, GM148, TS1R1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Makalowska, Sood, Faruque et al.: "Identification of six novel genes by experimental validation of GeneMachine predicted genes." in: Gene, Vol. 284, Issue 1-2, pp. 203-13, 2002 (PubMed).

Li, Staszewski, Xu et al.: "Human receptors for sweet and umami taste." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 7, pp. 4692-6, 2002 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Validation Images
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