Taste Receptor, Type 1, Member 1 (TAS1R1) antibody

Antigen: Taste Receptor, Type 1, Member 1 (TAS1R1)

Synonyms: Gpr70, TR1, T1R1, GPR70, gm148, T1r1, TAS1R1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350951

Additional Information

Alternative name: taste receptor, type 1, member 1 (TAS1R1, TR1, T1R1, TS1R1)

Swiss-Prot: Q7RTX1

Immunogen: A synthetic peptide as a part of human taste receptor, type 1, member 1 (TAS1R1, TR1, T1R1, GPR70, gm148) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene. FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Taste receptor type 1 member 1 (precursor), G-protein, coupled receptor 70, TAS1R1, GPR70, T1R1, TR1, GM148, TS1R1.

Specificity: Appears to be specific for TAS1R1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Makalowska, Sood, Faruque et al.: "Identification of six novel genes by experimental validation of GeneMachine predicted genes." in: Gene, Vol. 284, Issue 1-2, pp. 203-13, 2002 (PubMed).

Li, Staszewski, Xu et al.: "Human receptors for sweet and umami taste." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 7, pp. 4692-6, 2002 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).