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Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 120-170), (Extracellular Domain) antibody

Details for Product No. ABIN350952, Supplier: Log in to see
Antigen
  • GPR70
  • T1R1
  • TR1
  • Gpr70
  • T1r1
Epitope
Extracellular Domain, AA 120-170
16
14
13
11
5
5
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
63
18
15
2
1
1
1
1
1
Host
Rabbit
68
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
38
22
17
13
8
3
1
Supplier
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Immunogen A synthetic peptide from aa region 120 -170 of the 1t extracellular domain of mouse TAS1R1 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TAS1R1.
Purification Whole serum
Alternative Name TAS1R1 (TAS1R1 Antibody Abstract)
Background Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms heterodimers with TAS1R3.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed strongly only in fungiform papillae. Also known as: Taste receptor type 1 member 1, Tas1r1, Gpr70, T1r1, Tr1, TS1R1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ariyasu, Matsumoto, Kyono et al.: "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose." in: In vitro cellular & developmental biology. Animal, Vol. 39, Issue 1-2, pp. 80-8, 2003 (PubMed).

Nelson, Chandrashekar, Hoon et al.: "An amino-acid taste receptor." in: Nature, Vol. 416, Issue 6877, pp. 199-202, 2002 (PubMed).

Nelson, Hoon, Chandrashekar et al.: "Mammalian sweet taste receptors." in: Cell, Vol. 106, Issue 3, pp. 381-90, 2001 (PubMed).

Montmayeur, Liberles, Matsunami et al.: "A candidate taste receptor gene near a sweet taste locus." in: Nature neuroscience, Vol. 4, Issue 5, pp. 492-8, 2001 (PubMed).

Li, Inoue, Reed et al.: "High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 12, Issue 1, pp. 13-6, 2001 (PubMed).