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Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 785-835) antibody

Details for Product No. ABIN350954
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Antigen
Synonyms GPR70, T1R1, TR1, Gpr70, T1r1
Epitope
AA 785-835
(8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(41), (20), (19), (2)
Host
Rabbit
(46), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (14), (11), (10), (7), (4), (1), (1)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN350954
454.67 $
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Immunogen A synthetic peptide from aa region 785-835 of mouse TAS1R1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and shares 92% identity with human's.
Specificity Specific for TAS1R1.
Purification Whole serum
Alternative Name TAS1R1
Background Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms heterodimers with TAS1R3.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed strongly only in fungiform papillae. Also known as: Taste receptor type 1 member 1, Tas1r1, Gpr70, T1r1, Tr1, TS1R1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Li, Inoue, Reed et al.: "High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 12, Issue 1, pp. 13-6, 2001 (PubMed).

Montmayeur, Liberles, Matsunami et al.: "A candidate taste receptor gene near a sweet taste locus." in: Nature neuroscience, Vol. 4, Issue 5, pp. 492-8, 2001 (PubMed).

Nelson, Hoon, Chandrashekar et al.: "Mammalian sweet taste receptors." in: Cell, Vol. 106, Issue 3, pp. 381-90, 2001 (PubMed).

Nelson, Chandrashekar, Hoon et al.: "An amino-acid taste receptor." in: Nature, Vol. 416, Issue 6877, pp. 199-202, 2002 (PubMed).

Ariyasu, Matsumoto, Kyono et al.: "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose." in: In vitro cellular & developmental biology. Animal, Vol. 39, Issue 1-2, pp. 80-8, 2003 (PubMed).

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