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Taste Receptor, Type 1, Member 3 (TAS1R3) (AA 450-550) antibody

Details for Product No. ABIN350960
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Antigen
Synonyms T1R3, Sac, T1r3, tas1r3
Epitope
AA 450-550
(14), (8), (7), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Zebrafish
(60), (22), (22), (17), (17)
Host
Rabbit
(51), (11), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(37), (28), (14), (10), (7), (5), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350960
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide form AA 450-550 of human TAS1R3 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for trpc5.
Purification whole serum
Alternative Name taste receptor, type 1, member 3 (TAS1R3, T1R3, TR3, TS1R3)
Background The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners.
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Taste receptor type 1 member 3, sweet taste receptor T1R3, TAS1R3, T1R3, TR3, TS1R3.
UniProt Q1MT27
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Li, Staszewski, Xu et al.: "Human receptors for sweet and umami taste." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 7, pp. 4692-6, 2002 (PubMed).

Ariyasu, Matsumoto, Kyono et al.: "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose." in: In vitro cellular & developmental biology. Animal, Vol. 39, Issue 1-2, pp. 80-8, 2003 (PubMed).

Jiang, Ji, Liu et al.: "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45068-75, 2004 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350960
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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