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Details for Product No. ABIN350967

Taste Receptor, Type 2, Member 12 Pseudogene (TAS2R12) antibody

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Antigen
Synonyms PS10, T2R12, TAS2R12, TAS2R26
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350967
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from mouse ChAT (choline O-acetyltransferase) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for ChAT.
Purity whole serum
Alternative Name taste receptor, type 2, member 12 pseuene (TAS2R12, T2R12, T2R26, TAS2R26)
Background Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli. SIMILARITY: Belongs to the G-protein coupled receptor T2R family Note: This protein was previously referred to as T2R26 by authors form Ref.1, and in a first attempt to adopt one commun nomenclature it is considered to be T2R12. It awaits further confirmation. Also known as: Putative Taste receptor type 2 member 12, T2R12, Taste receptor type 2 member 26, T2R26, TAS2R12,TAS2R26.
UniProt Q03059
Application Notes A dilution of 1 : 300 to 1 : 4000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Alternatives for antigen "Taste Receptor, Type 2, Member 12 Pseudogene (TAS2R12)", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1), (1)
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