Taste Receptor, Type 2, Member 12 Pseudogene (TAS2R12) antibody

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Antigen
  • PS10
  • T2R12
  • TAS2R12
  • TAS2R26
  • taste receptor, type 2, member 12 pseudogene
  • TAS2R12P
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from human taste receptor, type 2, member 12 pseudogene (TAS2R12, T2R12, T2R26, TAS2R26) conjugated to an immunogenic carrier protein was used as the antigen.
Purification Whole serum
Alternative Name TAS2R12
Background Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli. SIMILARITY: Belongs to the G-protein coupled receptor T2R family Note: This protein was previously referred to as T2R26 by authors form Ref.1, and in a first attempt to adopt one commun nomenclature it is considered to be T2R12. It awaits further confirmation. Also known as: Putative Taste receptor type 2 member 12, T2R12, Taste receptor type 2 member 26, T2R26, TAS2R12,TAS2R26.
Research Area Neurology
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Zhang, Hoon, Chandrashekar, Mueller, Cook, Wu, Zuker, Ryba: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

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