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TAS2R16 antibody (Taste Receptor, Type 2, Member 16) (AA 150-200)

Details for Product anti-TAS2R16 Antibody No. ABIN350970, Supplier: Log in to see
Antigen
  • Gm465
  • mGR18
  • mt2r40
  • T2R3
  • T2R16
  • T2R18
  • Tas2r16
  • Tas2r18
Epitope
AA 150-200
2
2
1
1
Reactivity
Human
21
1
Host
Rabbit
22
Clonality
Polyclonal
Conjugate
This TAS2R16 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
12
11
6
3
1
1
Supplier
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Immunogen A synthetic peptide from aa region 150-200 of human TAS2R16 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TAS2R16.
Purification Whole serum
Alternative Name TAS2R16 (TAS2R16 Antibody Abstract)
Background This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in a subset of gustducin-positive taste receptor cells of the tongue. POLYMORPHISM: The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780].
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell.
Miscellaneous: Confers bitter perception of salicin to non-taster mice. Also known as: Taste receptor type 2 member 16, TAS2R16, T2R16.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Fischer, Gilad, Man, Pääbo: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005

Hinrichs, Wang, Bufe, Kwon, Budde, Allen, Bertelsen, Evans, Dick, Rice, Foroud, Nurnberger, Tischfield, Kuperman, Crowe, Hesselbrock, Schuckit, Almasy, Porjesz, Edenberg, Begleiter, Meyerhof, Bierut, Goate: "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence." in: American journal of human genetics, Vol. 78, Issue 1, pp. 103-11, 2005

Mueller, Hoon, Erlenbach, Chandrashekar, Zuker, Ryba: "The receptors and coding logic for bitter taste." in: Nature, Vol. 434, Issue 7030, pp. 225-9, 2005

Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003

Zhang, Hoon, Chandrashekar, Mueller, Cook, Wu, Zuker, Ryba: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003

Bufe, Hofmann, Krautwurst, Raguse, Meyerhof: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002

Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002

Adler, Hoon, Mueller, Chandrashekar, Ryba, Zuker: "A novel family of mammalian taste receptors." in: Cell, Vol. 100, Issue 6, pp. 693-702, 2000

Chandrashekar, Mueller, Hoon, Adler, Feng, Guo, Zuker, Ryba: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000