Taste Receptor, Type 2, Member 16 (TAS2R16) (Cytoplasmic Domain) antibody

Antigen: Taste Receptor, Type 2, Member 16 (TAS2R16)

Synonyms: T2R16, T2R3, Tas2r16

Binding Site: Cytoplasmic Domain

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350971

Additional Information

Alternative name: taste receptor, type 2, member 16 (TAS2R16, T2R16)

UniProt: Q9JKU0

Immunogen: A synthetic peptide from a cytoplasmic domain of rat taste receptor, type 2, member 16 (TAS2R16, T2R16) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.<||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html"><||/a> Also known as: T2R16, T2R18, T2R3, Tas2r18, Tas2r3, Tas2r16, T2R16.

Specificity: Appears to be specific for TAS2R16.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Adler, Hoon, Mueller et al.: "A novel family of mammalian taste receptors." in: Cell, Vol. 100, Issue 6, pp. 693-702, 2000 (PubMed).

Chandrashekar, Mueller, Hoon et al.: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000 (PubMed).

Wu, Rozengurt, Yang et al.: "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 4, pp. 2392-7, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).