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Details for Product No. ABIN350974

Taste Receptor, Type 2, Member 4 (Tas2r108) (Cytoplasmic Domain) antibody

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Antigen
Synonyms T2R4, T2R16, Tas2r4, T2R108, T2r8, Tas2r8, mGR08, mt2r8, T2R1, tas2r4, tas2r1l
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350974
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from a cytoplasmic domain of mouse taste receptor, type 2, member 4 (Tas2r4, T2R4) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for MOR244-1, 2.
Purity whole serum
Alternative Name taste receptor, type 2, member 4 (Tas2r4, T2R4)
Background Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subunit: Forms heterodimers with TAS1R3.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Also known as: Tas2r4, Tas2r108, Tas2r8, T2R4, Taste receptor type 2 member 8, TA2R4.
UniProt Q9R0K4
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Adler, Hoon, Mueller et al.: "A novel family of mammalian taste receptors." in: Cell, Vol. 100, Issue 6, pp. 693-702, 2000 (PubMed).

Chandrashekar, Mueller, Hoon et al.: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Nelson, Munger, Boughter: "Taste sensitivities to PROP and PTC vary independently in mice." in: Chemical senses, Vol. 28, Issue 8, pp. 695-704, 2003 (PubMed).

Wu, Chen, Rozengurt: "Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat." in: Physiological genomics, Vol. 22, Issue 2, pp. 139-49, 2005 (PubMed).

Alternatives for antigen "Taste Receptor, Type 2, Member 4 (Tas2r108)", type "Antibodies"
Hosts (4), (2)
Reactivities (3), (3)
Applications (5), (3), (1), (1), (1), (1), (1), (1)
Epitopes (1), (1), (1), (1)
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