Taste Receptor, Type 2, Member 4 (Tas2r108) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350974
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Antigen
Synonyms T2R4, T2R1, tas2r4, tas2r1l, T2R108, T2r8, Tas2r4, Tas2r8, mGR08, mt2r8, T2R16
Epitope
Cytoplasmic Domain
(2), (1), (1)
Reactivity
Mouse (Murine)
(5), (1)
Host
Rabbit
(4), (1), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(5), (3), (1), (1)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN350974
454.67 $
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Immunogen A synthetic peptide from a cytoplasmic domain of mouse TAS2R4 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TAS2R4.
Purification Whole serum
Alternative Name TAS2R4
Background Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subunit: Forms heterodimers with TAS1R3.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Also known as: Tas2r4, Tas2r108, Tas2r8, T2R4, Taste receptor type 2 member 8, TA2R4.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Adler, Hoon, Mueller et al.: "A novel family of mammalian taste receptors." in: Cell, Vol. 100, Issue 6, pp. 693-702, 2000 (PubMed).

Chandrashekar, Mueller, Hoon et al.: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Nelson, Munger, Boughter: "Taste sensitivities to PROP and PTC vary independently in mice." in: Chemical senses, Vol. 28, Issue 8, pp. 695-704, 2003 (PubMed).

Wu, Chen, Rozengurt: "Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat." in: Physiological genomics, Vol. 22, Issue 2, pp. 139-49, 2005 (PubMed).

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