Taste Receptor, Type 2, Member 4 (Tas2r108) (cytoplasmic domain) antibody

Antigen: Taste Receptor, Type 2, Member 4 (Tas2r108)

Synonyms: T2R4, MGC163311, T2R16, Tas2r4, T2R1, tas2r4, tas2r1l

Epitope: cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350975

Additional Information

Alternative name: taste receptor, type 2, member 4 (Tas2r4, T2R4) (cytoplasmic domain)

Swiss-Prot: Q67ET0

Immunogen: A synthetic peptide from a cytoplasmic domain of rat taste receptor, type 2, member 4 (Tas2r4, T2R4) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in tongue, stomach and duodenum. Also known as: Tas2r4, Taste receptor type 2 member 4, TA2R4, Taste receptor type 2 member 20, T2R20.

Specificity: Appears to be specific for TAS2R4.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Wu, Chen, Rozengurt: "Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat." in: Physiological genomics, Vol. 22, Issue 2, pp. 139-49, 2005 (PubMed).