Taste Receptor, Type 2, Member 40 (TAS2R40) antibody

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Antigen
Synonyms GPR60, T2R40, T2R58, RGD1562314, Tas2r40, Tas2r44, mt2r33
Reactivity
Human, Rat (Rattus), Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350978
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide as a part of human taste receptor, type 2, member 40 (TAS2R40, T2R40, T2R58, GPR60) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for GRPR.
Purification whole serum
Alternative Name taste receptor, type 2, member 40 (TAS2R40, T2R40, T2R58, GPR60)
Background Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell. Also known as: Taste receptor type 2 member 40, T2R40, T2R58, G-protein coupled receptor 60, MGC126844,MGC126846.
UniProt P21729
Research Area Signaling, Hormones
Application Notes A dilution of 1 : 300 to 1 : 4000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Chandrashekar, Mueller, Hoon et al.: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000 (PubMed).

Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Bufe, Hofmann, Krautwurst et al.: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

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