Taste Receptor, Type 2, Member 42 (TAS2R42) antibody

Antigen: Taste Receptor, Type 2, Member 42 (TAS2R42)

Synonyms: T2R24, T2R55, hT2R55, T2R67

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350980

Additional Information

Alternative name: taste receptor, type 2, member 42 (TAS2R42, T2R42, T2R55, hT2R55, T2R24)

UniProt: Q7RTR8

Immunogen: A synthetic peptide from human taste receptor, type 2, member 42 (TAS2R42, T2R42, T2R55, hT2R55, T2R24) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Also known as: Taste receptor type 2 member 42, T2R42, T2R55, TAS2R42, TAS2R55, hT2R55, T2R24.

Specificity: Appears to be specific for TAS2R42.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Shi, Zhang, Yang et al.: "Adaptive diversification of bitter taste receptor genes in Mammalian evolution." in: Molecular biology and evolution, Vol. 20, Issue 5, pp. 805-14, 2003 (PubMed).

Fischer, Gilad, Man et al.: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005 (PubMed).

Scherer, Muzny, Buhay et al.: "The finished DNA sequence of human chromosome 12." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).