Taste Receptor, Type 2, Member 42 (TAS2R42) antibody

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  • T2R24
  • T2R55
  • TAS2R55
  • hT2R55
  • T2R67
  • taste receptor, type 2, member 42
  • TAS2R42
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from human TAS2R42 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TAS2R42.
Purification Whole serum
Alternative Name TAS2R42
Background Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli. Also known as: Taste receptor type 2 member 42, T2R42, T2R55, TAS2R42, TAS2R55, hT2R55, T2R24.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Scherer, Muzny, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker, Milosavljevic, Miner, Montgomery et al.: "The finished DNA sequence of human chromosome 12. ..." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).

Fischer, Gilad, Man, Pääbo: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005 (PubMed).

Shi, Zhang, Yang, Zhang: "Adaptive diversification of bitter taste receptor genes in Mammalian evolution." in: Molecular biology and evolution, Vol. 20, Issue 5, pp. 805-14, 2003 (PubMed).