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Taste Receptor, Type 2, Member 43 (TAS2R43) antibody

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  • T2R43
  • T2R46
  • T2R52
  • TAS2R43
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from human TAS2R43 conjugated to blue carrier protein was used as the antigen. The antibody generated using this antigen is expected to also recognise TAS2R44, TAS2R45 and TAS2R47.
Specificity Specific for TAS2R43 (and also TAS2R44, TAS2R45 and TAS2R47.
Purification Whole serum
Alternative Name TAS2R43 (TAS2R43 Antibody Abstract)
Background Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli. Also known as: Taste receptor type 2 member 43, T2R43, T2R52, TAS2R43.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Kuhn, Bufe, Winnig, Hofmann, Frank, Behrens, Lewtschenko, Slack, Ward, Meyerhof: "Bitter taste receptors for saccharin and acesulfame K." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 45, pp. 10260-5, 2004

Conte, Ebeling, Marcuz, Nef, Andres-Barquin: "Identification and characterization of human taste receptor genes belonging to the TAS2R family." in: Cytogenetic and genome research, Vol. 98, Issue 1, pp. 45-53, 2003

Zhang, Hoon, Chandrashekar, Mueller, Cook, Wu, Zuker, Ryba: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003

Bufe, Hofmann, Krautwurst, Raguse, Meyerhof: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002

Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002

Chandrashekar, Mueller, Hoon, Adler, Feng, Guo, Zuker, Ryba: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000