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|+1 404 474 4654|
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Taste Receptor, Type 2, Member 45 (TAS2R45) antibody
|Synonyms||GPR59, ZG24P, MGC119923, MGC119924, MGC119925|
Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||taste receptor, type 2, member 45 (TAS2R45, T2R45, GPR59, ZG24P)|
|Immunogen||A synthetic peptide as a part of human taste receptor, type 2, member 45 (TAS2R45, T2R45, GPR59, ZG24P) conjugated to immunogenic carrier protein was used as the immunogen. The antibody generated using this antigen is expected to also recognise TAS2R43, TAS2R44 and TAS2R47.|
|Description||FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html"> The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/">olfactory Receptor Data Base: ORDB <||/a> Also known as: Taste receptor type 2 member 45, TAS2R45, GPR59, ZG24P, G-protein coupled receptor 59, MGC119923, MGC119924, MGC119925.|
|Specificity||Appears to be specific for TAS2R45 ( and also TAS2R43, TAS2R44 and TAS2R47. See the Immunogen)|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).
Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).
Bufe, Hofmann, Krautwurst et al.: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002 (PubMed).
Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).