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Details for Product No. ABIN350985

Taste Receptor, Type 2, Member 45 (TAS2R45) antibody

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Antigen
Synonyms GPR59, T2R45, ZG24P
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350985
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human taste receptor, type 2, member 45 (TAS2R45, T2R45, GPR59, ZG24P) conjugated to immunogenic carrier protein was used as the immunogen. The antibody generated using this antigen is expected to also recognise TAS2R43, TAS2R44 and TAS2R47.
Specificity Appears to be specific for TAS2R45 ( and also TAS2R43, TAS2R44 and TAS2R47. See the Immunogen)
Purity whole serum
Alternative Name taste receptor, type 2, member 45 (TAS2R45, T2R45, GPR59, ZG24P)
Background Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds, individual taste cells can discriminate among bitter stimuli. Also known as: Taste receptor type 2 member 45, TAS2R45, GPR59, ZG24P, G-protein coupled receptor 59, MGC119923, MGC119924,MGC119925.
UniProt P59539
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Bufe, Hofmann, Krautwurst et al.: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Alternatives for antigen "Taste Receptor, Type 2, Member 45 (TAS2R45)", type "Antibodies"
Hosts (10)
Reactivities (10)
Applications (10), (8), (1), (1)
Epitopes (7)
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