Taste Receptor, Type 2, Member 46 (TAS2R46) antibody

Antigen: Taste Receptor, Type 2, Member 46 (TAS2R46)

Synonyms: T2R46, T2R54, MGC134865, TAS2R43

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350986

Additional Information

Alternative name: taste receptor, type 2, member 46 (TAS2R46, T2R46, T2R54)

UniProt: P59540

Immunogen: A synthetic peptide from human taste receptor, type 2, member 46 (TAS2R46, T2R46, T2R54) conjugated to an immunogenic carrier protein was used as the immunogen. The antibodies generated using this antigen is expected to also recognise gene products of TAS2R43, TAS2R44, TAS2R47 and TAS2R49.

Format: Lyophilized

Description: FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.<||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" ><||/a> Also known as: Taste receptor type 2 member 46, T2R54, TAS2R46, MGC134865.

Specificity: Appears to be specific for TAS2R46 ( and also TAS2R43, TAS2R44, TAS2R47 and TAS2R49. See the Immunogen).

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Bufe, Hofmann, Krautwurst et al.: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Conte, Ebeling, Marcuz et al.: "Identification and characterization of human taste receptor genes belonging to the TAS2R family." in: Cytogenetic and genome research, Vol. 98, Issue 1, pp. 45-53, 2003 (PubMed).

Fischer, Gilad, Man et al.: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005 (PubMed).