Taste Receptor, Type 2, Member 7 (TAS2R7) (3rd Extracellular Domain) antibody

Antigen: Taste Receptor, Type 2, Member 7 (TAS2R7)

Synonyms: T2R7, TRB4, MGC142121, STC74, T2R30, Tas2r7, mt2r42, Tas2r30, TRB1, T2R16, mGR16, mt2r56, Tas2r14, Tas2r16, Patr-T2R7, t2r1, t2r7, trb4

Binding Site: 3rd Extracellular Domain

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus), Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350994

Additional Information

Alternative name: taste receptor, type 2, member 7 (Tas2r7, T2R7)

UniProt: P59530

Immunogen: A synthetic peptide from 3d extracellular domain of rat taste receptor, type 2, member 7 (Tas2r7, T2R7) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.

Format: Lyophilized

Description: FUNCTION: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues. Also known as: Taste receptor type 2 member 7, T2R7, T2R6, T2R30, STC7-4, mT2R42, Tas2r130, Tas2r6, Tas2r7.

Specificity: Appears to be specific for TAS2R7.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Wu, Rozengurt, Yang et al.: "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 4, pp. 2392-7, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Shi, Zhang, Yang et al.: "Adaptive diversification of bitter taste receptor genes in Mammalian evolution." in: Molecular biology and evolution, Vol. 20, Issue 5, pp. 805-14, 2003 (PubMed).

Scalzo, Wheat, Dubbelde et al.: "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus." in: Immunogenetics, Vol. 55, Issue 6, pp. 370-8, 2003 (PubMed).