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Details for Product No. ABIN350994

Taste Receptor, Type 2, Member 7 (TAS2R7) (Extracellular Domain) antibody

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Antigen
Synonyms T2R7, TRB4, STC74, T2R30, Tas2r7, mt2r42, Tas2r30, Tas2r13, Patr-T2R7, t2r1, t2r7, trb4
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350994
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from 3d extracellular domain of rat taste receptor, type 2, member 7 (Tas2r7, T2R7) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse.
Specificity Specific for 5HT4R receptor.
Purity whole serum
Alternative Name taste receptor, type 2, member 7 (Tas2r7, T2R7)
Background Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues. Also known as: Taste receptor type 2 member 7, T2R7, T2R6, T2R30, STC7-4, mT2R42, Tas2r130, Tas2r6, Tas2r7.
UniProt Q62758
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Wu, Rozengurt, Yang et al.: "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 4, pp. 2392-7, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Shi, Zhang, Yang et al.: "Adaptive diversification of bitter taste receptor genes in Mammalian evolution." in: Molecular biology and evolution, Vol. 20, Issue 5, pp. 805-14, 2003 (PubMed).

Scalzo, Wheat, Dubbelde et al.: "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus." in: Immunogenetics, Vol. 55, Issue 6, pp. 370-8, 2003 (PubMed).

Alternatives for antigen "Taste Receptor, Type 2, Member 7 (TAS2R7)", type "Antibodies"
Hosts (41), (1)
Reactivities (41), (1), (1)
Applications (24), (20), (16), (6), (6), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (7), (6), (2), (2), (2), (1)
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