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Taste Receptor, Type 2, Member 7 (TAS2R7) (AA 200-250) antibody

Details for Product No. ABIN350995, Supplier: Log in to see
Antigen
  • t2r1
  • t2r7
  • trb4
  • T2R7
  • Tas2r13
  • Tas2r7
  • STC74
  • T2R30
  • Tas2r30
  • mt2r42
  • TRB4
  • Patr-T2R7
  • taste receptor, type 2, member 7
  • taste receptor, type 2, member 121
  • taste receptor, type 2, member 130
  • TAS2R7
  • tas2r7
  • Tas2r121
  • Tas2r130
Epitope
AA 200-250
15
12
3
2
1
1
1
1
1
1
Reactivity
Human
45
2
2
Host
Rabbit
47
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
34
22
13
6
3
2
1
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Immunogen A synthetic peptide from aa region 200-250 of human TAS2R7 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TAS2R7.
Purification Whole serum
Alternative Name TAS2R7 (TAS2R7 Antibody Abstract)
Background This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell. Also known as: Taste receptor type 2 member 7, T2R7, Taste receptor family B member 4, TRB4, TAS2R7, MGC142121.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Fischer, Gilad, Man, Pääbo: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005 (PubMed).

Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Zhang, Hoon, Chandrashekar, Mueller, Cook, Wu, Zuker, Ryba: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Margolskee: "Molecular mechanisms of bitter and sweet taste transduction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 1-4, 2002 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Adler, Hoon, Mueller, Chandrashekar, Ryba, Zuker: "A novel family of mammalian taste receptors." in: Cell, Vol. 100, Issue 6, pp. 693-702, 2000 (PubMed).

Chandrashekar, Mueller, Hoon, Adler, Feng, Guo, Zuker, Ryba: "T2Rs function as bitter taste receptors." in: Cell, Vol. 100, Issue 6, pp. 703-11, 2000 (PubMed).