Did you know that you can buy products from over 140 different suppliers from us?

Telomerase Reverse Transcriptase (TERT) (AA 400-450) antibody

Details for Product No. ABIN350999
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms Tert, tert, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, TR, chTERT, ATTERT, F5E19.190, F5E19_190, telomerase reverse transcriptase
Epitope
AA 400-450
(17), (14), (9), (7), (6), (6), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(142), (45), (39), (1), (1)
Host
Rabbit
(138), (10), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(82), (61), (41), (30), (20), (19), (16), (14), (10), (7), (5)
Pubmed 10 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350999
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from aa region 400-450 of human Telomerase reverse transcriptase (TERT) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TERT.
Purification Whole serum
Alternative Name TERT
Target Type Tag
Background Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
Subcellular location: Nucleus. Telomere. DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis. Also known as: Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT.
Research Area DNA/RNA, Cell Cycle, Enzymes
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Nakamura, Morin, Chapman et al.: "Telomerase catalytic subunit homologs from fission yeast and human." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 955-9, 1997 (PubMed).

Meyerson, Counter, Eaton et al.: "hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization." in: Cell, Vol. 90, Issue 4, pp. 785-95, 1997 (PubMed).

Wick, Zubov, Hagen: "Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)." in: Gene, Vol. 232, Issue 1, pp. 97-106, 1999 (PubMed).

Hisatomi, Ohyashiki, Ohyashiki et al.: "Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene." in: Neoplasia (New York, N.Y.), Vol. 5, Issue 3, pp. 193-7, 2003 (PubMed).

Song, Li, Chen et al.: "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length." in: Biochemical and biophysical research communications, Vol. 316, Issue 4, pp. 1116-23, 2004 (PubMed).

Tao, Wollscheid, OBrien et al.: "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." in: Nature methods, Vol. 2, Issue 8, pp. 591-8, 2005 (PubMed).

Armanios, Chen, Chang et al.: "Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 44, pp. 15960-4, 2005 (PubMed).

Nousiainen, Silljé, Sauer et al.: "Phosphoproteome analysis of the human mitotic spindle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5391-6, 2006 (PubMed).

Matsubara, Murata, Watanabe et al.: "Coronary artery disease and a functional polymorphism of hTERT." in: Biochemical and biophysical research communications, Vol. 348, Issue 2, pp. 669-72, 2006 (PubMed).

Tsakiri, Cronkhite, Kuan et al.: "Adult-onset pulmonary fibrosis caused by mutations in telomerase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 18, pp. 7552-7, 2007 (PubMed).

Validation Images
back to top