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Telomerase Reverse Transcriptase (TERT) (AA 2-50) antibody

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Synonyms Tert, tert, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, TR, chTERT, ATTERT, F5E19.190, F5E19_190, telomerase reverse transcriptase
AA 2-50
(23), (18), (16), (13), (13), (13), (11), (9), (9), (8), (8), (6), (6), (6), (6), (5), (5), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(218), (55), (44), (4), (2)
(225), (13), (6), (2)
(16), (15), (13), (7), (7), (7), (4), (3), (3), (3), (3), (3), (3), (3), (3)
Immunohistochemistry (IHC), Western Blotting (WB)
(136), (125), (38), (35), (30), (29), (20), (14), (11), (9), (7), (4), (4), (1)
Pubmed 10 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 2-50 of human TERT conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TERT.
Purification Whole serum
Alternative Name TERT (TERT Antibody Abstract)
Background Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
Subcellular location: Nucleus. Telomere. DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis. Also known as: Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT.
Research Area DNA/RNA, Cell Cycle, Enzymes
Pathways Telomere Maintenance
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Tsakiri, Cronkhite, Kuan et al.: "Adult-onset pulmonary fibrosis caused by mutations in telomerase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 18, pp. 7552-7, 2007 (PubMed).

Matsubara, Murata, Watanabe et al.: "Coronary artery disease and a functional polymorphism of hTERT." in: Biochemical and biophysical research communications, Vol. 348, Issue 2, pp. 669-72, 2006 (PubMed).

Nousiainen, Silljé, Sauer et al.: "Phosphoproteome analysis of the human mitotic spindle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5391-6, 2006 (PubMed).

Armanios, Chen, Chang et al.: "Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 44, pp. 15960-4, 2005 (PubMed).

Tao, Wollscheid, OBrien et al.: "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." in: Nature methods, Vol. 2, Issue 8, pp. 591-8, 2005 (PubMed).

Song, Li, Chen et al.: "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length." in: Biochemical and biophysical research communications, Vol. 316, Issue 4, pp. 1116-23, 2004 (PubMed).

Hisatomi, Ohyashiki, Ohyashiki et al.: "Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene." in: Neoplasia (New York, N.Y.), Vol. 5, Issue 3, pp. 193-7, 2003 (PubMed).

Wick, Zubov, Hagen: "Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)." in: Gene, Vol. 232, Issue 1, pp. 97-106, 1999 (PubMed).

Meyerson, Counter, Eaton et al.: "hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization." in: Cell, Vol. 90, Issue 4, pp. 785-95, 1997 (PubMed).

Nakamura, Morin, Chapman et al.: "Telomerase catalytic subunit homologs from fission yeast and human." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 955-9, 1997 (PubMed).

Catalog No. ABIN351001
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