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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
TGN (Trans-Golgi network, TGN51, TGN46, TGN48, TGN38) (Cytoplasmic Domain) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the cytoplasmic part of mouse TGN38 conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat, human (TGN46, TGN48, TGN51).|
|Description||FUNCTION: May be involved in regulating membrane traffic to and from trans-Golgi network. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note: Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes. TISSUE SPECIFICITY: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells. MISCELLANEOUS: Not found in strains BALB/c, C57BL/6 and DBA/2. Also known as: Trans-Golgi network protein TGN51, TGN46, TGN48, TGN38 homolog, Trans-Golgi network integral membrane protein 2, TGOLN2.|
|Specificity||Appears to be specific for TGN38 (or TGN46, TGN48, TGN51 in human).|
|Application Notes||IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Kasai, Takahashi, Murakami et al.: "Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse." in: The Journal of biological chemistry, Vol. 270, Issue 24, pp. 14471-6, 1995 (PubMed).
Wu, MacCoss, Mardones et al.: "Organellar proteomics reveals Golgi arginine dimethylation." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2907-19, 2004 (PubMed).
Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).
Dai, Jin, Sheng et al.: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).
Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).
|Hosts||Sheep (2), Rabbit (1)|
|Applications||Immunohistochemistry (IHC) (3), Western Blotting (WB) (3)|
|Epitopes||Cytoplasmic Domain (3)|