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T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) antibody

Details for Product No. ABIN351007
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Antigen
Synonyms TIAM1, tiam1, AI847750, D16Ium10, D16Ium10e
Reactivity
Human, Mouse (Murine)
(33), (18), (14), (12), (12), (12)
Host
Rabbit
(29), (4), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(19), (10), (10), (7), (5)
Pubmed 8 references available
Quantity 100 µL
Options
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Catalog No. ABIN351007
454.67 $
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Immunogen A synthetic peptide from human TIAM1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
Specificity Specific for TIAM1.
Purification Whole serum
Alternative Name TIAM 1
Background Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
Subunit: Interacts with BAIAP2.
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. Also known as: TIAM-1, TIAM1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
anti-T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1) antibody IF on 1 day- old mouse cortical cell culture using Rabbit antibody to T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1, TIAM1): whole serum (ABIN351007) at 1: 2000 dilution. DAPI counter stained.
General Habets, van der Kammen, Stam et al.: "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin." in: Oncogene, Vol. 10, Issue 7, pp. 1371-6, 1995 (PubMed).

Habets, van der Kammen, Jenkins et al.: "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16." in: Cytogenetics and cell genetics, Vol. 70, Issue 1-2, pp. 48-51, 1995 (PubMed).

Michiels, Habets, Stam et al.: "A role for Rac in Tiam1-induced membrane ruffling and invasion." in: Nature, Vol. 375, Issue 6529, pp. 338-40, 1995 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Worthylake, Rossman, Sondek: "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1." in: Nature, Vol. 408, Issue 6813, pp. 682-8, 2000 (PubMed).

Connolly, Rice, Feig et al.: "Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation." in: Molecular and cellular biology, Vol. 25, Issue 11, pp. 4602-14, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Cao, Yu, Banh et al.: "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 9, pp. 5864-76, 2007 (PubMed).

Validation Images
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