TMP21 (TEMP21, TMED10,transmembrane protein Tmp21) (C-Term) antibody

Antigen: TMP21 (TEMP21, TMED10,transmembrane protein Tmp21)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351013

Additional Information

UniProt: P49755

Immunogen: A synthetic peptide from the c-terminal of TMP21 (TEMP21, TMED10, Transmembrane protein Tmp21) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including rat and mouse.

Format: Lyophilized

Isotype: IgG

Description: FUNCTION: Involved in vesicular protein trafficking. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein; Lumenal side. Melanosome. TISSUE SPECIFICITY: Ubiquitous. Also known as: TEMP21, 21 kDatransmembrane-trafficking protein,transmembrane protein Tmp21, Tmp-21-I, p24delta, TMED10, TMEDA.

Specificity: Appears to be specific for TMP21.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Sherrington, Rogaev, Liang et al.: "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." in: Nature, Vol. 375, Issue 6534, pp. 754-60, 1995 (PubMed).

Blum, Feick, Puype et al.: "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 17183-9, 1996 (PubMed).

Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).

Wu, MacCoss, Mardones et al.: "Organellar proteomics reveals Golgi arginine dimethylation." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2907-19, 2004 (PubMed).

Chi, Valencia, Hu et al.: "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." in: Journal of proteome research, Vol. 5, Issue 11, pp. 3135-44, 2006 (PubMed).