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Trace Amine Associated Receptor 1 (TAAR1) (AA 210-260) antibody

Details for Product No. ABIN351019, Supplier: Login to see
Antigen
  • RP11-295F4.9
  • TA1
  • TAR1
  • TRAR1
  • Tar1
  • Trar1
  • taR-1
Epitope
AA 210-260
7
7
5
4
3
2
2
1
Reactivity
Human
38
7
7
4
2
1
Host
Rabbit
40
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
24
22
14
5
1
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Immunogen A synthetic peptide from aa region 210-260 of human TAAR1 conjugated to blue carrier Protein was used as the antigen.
Specificity Specific for TAAR1.
Purification Whole serum
Alternative Name TAAR1 (TAAR1 Antibody Abstract)
Background Function: Receptor fortrace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine.trace amines are biogenic amines present in very low levels in mammalian tissues. Although sometrace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestin. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle, and spleen. Also known as:trace amine receptor 1, TaR-1, TA1, TAR1, TRAR1.
Pathways
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Lindemann, Ebeling, Kratochwil et al.: "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." in: Genomics, Vol. 85, Issue 3, pp. 372-85, 2005 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Bunzow, Sonders, Arttamangkul et al.: "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor." in: Molecular pharmacology, Vol. 60, Issue 6, pp. 1181-8, 2001 (PubMed).

Borowsky, Adham, Jones et al.: "Trace amines: identification of a family of mammalian G protein-coupled receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 8966-71, 2001 (PubMed).