Trace Amine Associated Receptor 1 (TAAR1) antibody

Details for Product No. ABIN351019
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Synonyms Tar1, Trar1, taR-1, RP11-295F4.9, TA1, TAR1, TRAR1
Mouse (Murine)
(29), (11), (5), (5), (2), (1)
(30), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(22), (20), (8), (3), (1)
Pubmed 4 references available
Catalog no. ABIN351019
Quantity 100 µL
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Immunogen A synthetic peptide from human TAAR1 conjugated to an immunogenic carrier Protein was used as the antigen.
Specificity Specific for ATG16L1.
Purification whole serum
Alternative Name trace amine-associated receptor 1 (TAAR1)
Background Function: Receptor fortrace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine.trace amines are biogenic amines present in very low levels in mammalian tissues. Although sometrace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestin. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle, and spleen. Also known as:trace amine receptor 1, TaR-1, TA1, TAR1, TRAR1.
UniProt Q8C0J2
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Borowsky, Adham, Jones et al.: "Trace amines: identification of a family of mammalian G protein-coupled receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 8966-71, 2001 (PubMed).

Bunzow, Sonders, Arttamangkul et al.: "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor." in: Molecular pharmacology, Vol. 60, Issue 6, pp. 1181-8, 2001 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6...." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Lindemann, Ebeling, Kratochwil et al.: "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." in: Genomics, Vol. 85, Issue 3, pp. 372-85, 2005 (PubMed).

Hosts (30), (2)
Reactivities (29), (11), (5), (5), (2), (1)
Applications (22), (20), (8), (3), (1)
Epitopes (7), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
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