Trace Amine Associated Receptor 1 (TAAR1) (AA 200-245) antibody

Details for Product No. ABIN351020
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Synonyms Tar1, Trar1, taR-1, RP11-295F4.9, TA1, TAR1, TRAR1
AA 200-245
(7), (3), (3), (3), (2), (1), (1), (1), (1), (1)
(28), (11), (6), (5), (2), (1)
(29), (2), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(22), (20), (8), (3), (1)
Pubmed 2 references available
Catalog no. ABIN351020
Quantity 100 µL
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Immunogen A synthetic peptide from AA 200-245 of mouse TAAR1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SNAP-25.
Purification whole serum
Alternative Name trace amine-associated receptor 1 (TAAR1)
Background Function: Receptor fortrace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine.trace amines are biogenic amines present in very low levels in mammalian tissues. Although sometrace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Widely distributed throughout the brain. Strongly expressed in the mitral cell layer of theolfactory bulb, piriform cortex, the arcuate, motor, and mesencephalic trigeminal nuclei, lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells, and ventral horn of the spinal cord. Moderately expressed in the frontal, entorhinal, and agranular cortices, the ventral pallidum, thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal raphe, and gigantocellular reticular nuclei. Weakly expressed in the septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal horn. Particularly interesting is the moderate expression in several monoaminergic cell groups, namely the dorsal raphe, the locus coeruleus, and the ventral tegmental area. Also known as:trace amine receptor 1, TaR-1, Ta1, Tar1, Trar1.
UniProt P60880
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Borowsky, Adham, Jones et al.: "Trace amines: identification of a family of mammalian G protein-coupled receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 8966-71, 2001 (PubMed).

Lindemann, Ebeling, Kratochwil et al.: "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." in: Genomics, Vol. 85, Issue 3, pp. 372-85, 2005 (PubMed).

Hosts (29), (2), (1)
Reactivities (28), (11), (6), (5), (2), (1)
Applications (22), (20), (8), (3), (1)
Epitopes (7), (3), (3), (3), (2), (1), (1), (1), (1), (1)
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