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Ras Homolog Gene Family, Member A (RHOA) antibody

Details for Product No. ABIN351037
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Antigen
Synonyms ARHA, ARH12, RHO12, RHOH12, Arha, Arha1, Arha2, arha, rhoa, xrhoa, RHO1, arha2, arh12, rho12, rhoh12
Reactivity
Human
(91), (49), (45), (25), (25), (14), (1), (1), (1), (1)
Host
Rabbit
(71), (20), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(74), (45), (21), (20), (19), (8), (4), (2), (2), (1)
Pubmed 5 references available
Quantity 500 µg
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN351037
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide as a part of human, rat, mouse, chicken, dog, bovine, frog, zebrafish, orangutan Transforming protein RhoA (Arha, Arha2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for MAS1L.
Purification IgG
Alternative Name Transforming protein RhoA (Arha, Arha2)
Background Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1.
Subunit: Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with RGNEF.
Subcellular location: Cell membrane, Lipid-anchor, Cytoplasmic side. Cytoplasm, cytoskeleton. Also known as: Arha, Arha2, ras homolog gene family member A, MGC72339.
UniProt P35410
Research Area Neurology, Apoptosis/Necrosis
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Yoshimura, Sakai, Nakashima et al.: "Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation." in: Brain research. Molecular brain research, Vol. 45, Issue 1, pp. 90-8, 1997 (PubMed).

Rihet, Vielh, Camonis et al.: "Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors." in: Journal of cancer research and clinical oncology, Vol. 127, Issue 12, pp. 733-8, 2001 (PubMed).

Snyder, Worthylake, Rossman et al.: "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors." in: Nature structural biology, Vol. 9, Issue 6, pp. 468-75, 2002 (PubMed).

Dubash, Wennerberg, Garcuia-Mata et al.: "A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin." in: Journal of cell science, Vol. 120, Issue Pt 22, pp. 3989-98, 2007 (PubMed).

El-Sibai, Pertz, Pang et al.: "RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells." in: Experimental cell research, Vol. 314, Issue 7, pp. 1540-52, 2008 (PubMed).

Hosts (71), (20), (2), (1)
Reactivities (91), (49), (45), (25), (25), (14), (1), (1), (1), (1)
Applications (74), (45), (21), (20), (19), (8), (4), (2), (2), (1)
Conjugates (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (8), (5), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN351037
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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