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Ras Homolog Gene Family, Member A (RHOA) antibody
|Synonyms||ARHA, ARH12, RHO12, RHOH12, Arha, Arha1, Arha2, arha, arha2, xrhoa, MGC53405, arh12, rho12, rhoh12, MGC69542|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Transforming protein RhoA (Arha, Arha2)|
|Immunogen||A synthetic peptide as a part of human, rat, mouse, chicken, dog, bovine, frog, zebrafish, orangutan Transforming protein RhoA (Arha, Arha2) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1. SUBUNIT: Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with RGNEF. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Also known as: Arha, Arha2, ras homolog gene family member A, MGC72339.|
|Specificity||Appears to be specific for RhOA.|
|Application Notes||IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Yoshimura, Sakai, Nakashima et al.: "Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation." in: Brain research. Molecular brain research, Vol. 45, Issue 1, pp. 90-8, 1997 (PubMed).
Rihet, Vielh, Camonis et al.: "Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors." in: Journal of cancer research and clinical oncology, Vol. 127, Issue 12, pp. 733-8, 2001 (PubMed).
Snyder, Worthylake, Rossman et al.: "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors." in: Nature structural biology, Vol. 9, Issue 6, pp. 468-75, 2002 (PubMed).
Dubash, Wennerberg, Garcuia-Mata et al.: "A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin." in: Journal of cell science, Vol. 120, Issue Pt 22, pp. 3989-98, 2007 (PubMed).
El-Sibai, Pertz, Pang et al.: "RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells." in: Experimental cell research, Vol. 314, Issue 7, pp. 1540-52, 2008 (PubMed).