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Details for Product No. ABIN351038

Ras Homolog Gene Family, Member A (RHOA) antibody

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Antigen
Synonyms ARHA, ARH12, RHO12, RHOH12, Arha, Arha1, Arha2, arha, rhoa, xrhoa, RHO1, arha2, arh12, rho12, rhoh12
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine), Chicken, Dog (Canine), Cow (Bovine), Frog, Zebrafish, Orang-Utan
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN351038
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, rat, mouse, chicken, dog, bovine, frog, zebrafish, orangutan Transforming protein RhoA (Arha, Arha2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for RhOA.
Purity whole serum
Alternative Name Transforming protein RhoA (Arha, Arha2)
Background Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1.
Subunit: Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with RGNEF.
Subcellular location: Cell membrane, Lipid-anchor, Cytoplasmic side. Cytoplasm, cytoskeleton. Also known as: Arha, Arha2, ras homolog gene family member A, MGC72339.
UniProt P61586
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Yoshimura, Sakai, Nakashima et al.: "Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation." in: Brain research. Molecular brain research, Vol. 45, Issue 1, pp. 90-8, 1997 (PubMed).

Rihet, Vielh, Camonis et al.: "Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors." in: Journal of cancer research and clinical oncology, Vol. 127, Issue 12, pp. 733-8, 2001 (PubMed).

Snyder, Worthylake, Rossman et al.: "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors." in: Nature structural biology, Vol. 9, Issue 6, pp. 468-75, 2002 (PubMed).

Dubash, Wennerberg, Garcuia-Mata et al.: "A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin." in: Journal of cell science, Vol. 120, Issue Pt 22, pp. 3989-98, 2007 (PubMed).

El-Sibai, Pertz, Pang et al.: "RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells." in: Experimental cell research, Vol. 314, Issue 7, pp. 1540-52, 2008 (PubMed).

Alternatives for antigen "Ras Homolog Gene Family, Member A (RHOA)", type "Antibodies"
Hosts (59), (19), (3), (1)
Reactivities (79), (43), (42), (28), (28), (17), (3), (3), (3), (1), (1), (1)
Applications (63), (42), (21), (20), (13), (8), (3), (2), (2), (2), (1)
Conjugates (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (14), (8), (5), (1), (1), (1), (1), (1), (1)
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