Transmembrane Channel-Like 3 (Tmc3) (1st Cytoplasmic Loop) antibody

Antigen: Transmembrane Channel-Like 3 (Tmc3)

Synonyms: 9030203A06

Binding Site: 1st Cytoplasmic Loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351042

Additional Information

Alternative name: transmembrane channel like protein 3 (TMC3)

UniProt: Q7Z5M5

Immunogen: A synthetic from the 1t cytoplasmic loop of human transmembrane channel like protein 3 (TMC3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in most neuronal organs and also in some non-neuronal tissues. Also known as: TMC3.

Specificity: Appears to be specific for TMC3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 400 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Keresztes, Mutai, Heller: "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins." in: BMC genomics, Vol. 4, Issue 1, pp. 24, 2003 (PubMed).

Kurima, Yang, Sorber et al.: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003 (PubMed).

Zody, Garber, Sharpe et al.: "Analysis of the DNA sequence and duplication history of human chromosome 15." in: Nature, Vol. 440, Issue 7084, pp. 671-5, 2006 (PubMed).

Yu, Zhu, Chan et al.: "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." in: Journal of proteome research, Vol. 6, Issue 11, pp. 4150-62, 2007 (PubMed).