Tmc2 antibody (Transmembrane Channel-Like 2) (4th Cytoplasmic Loop)

Details for Product anti-Tmc2 Antibody No. ABIN351046, Supplier: Log in to see
Antigen
  • C20orf145
  • dJ686C3.3
  • CWEA2
  • transmembrane channel-like 2
  • transmembrane channel-like gene family 2
  • TMC2
  • Tmc2
Epitope
4th Cytoplasmic Loop
2
1
1
Reactivity
Human
7
5
4
2
2
2
2
2
1
1
1
1
Host
Rabbit
8
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
7
2
1
1
1
1
Options
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TMC2.
Purification Whole serum
Alternative Name TMC2
Background Function: May be required for the normal function of cochlear hair cells.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Inner ear and testis.
Developmental stage: Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20. Also known as:transmembrane cochlear-expressed protein 2, TMC2.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Kurima, Peters, Yang, Riazuddin, Ahmed, Naz, Arnaud, Drury, Mo, Makishima, Ghosh, Menon, Deshmukh, Oddoux, Ostrer, Khan, Riazuddin, Deininger, Hampton, Sullivan, Battey, Keats, Wilcox, Friedman, Griffith: "Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function." in: Nature genetics, Vol. 30, Issue 3, pp. 277-84, 2002 (PubMed).