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Transmembrane Channel-Like 2 (Tmc2) (4th Cytoplasmic Loop) antibody
|Synonyms||C20orf145, dJ686C3.3, CWEA2|
4th Cytoplasmic Loop
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||transmembrane channel-like protein 2 (TMC2)|
|Immunogen||A synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: May be required for the normal function of cochlear hair cells. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Inner ear and testis. DEVELOPMENTAL STAGE: Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20. Also known as:transmembrane cochlear-expressed protein 2, TMC2.|
|Specificity||Appears to be specific for TMC2.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).
Kurima, Peters, Yang et al.: "Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function." in: Nature genetics, Vol. 30, Issue 3, pp. 277-84, 2002 (PubMed).
Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
|Reactivities||Human (2), Mouse (Murine) (2), Chicken (1), Rat (Rattus) (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (4), ELISA (1), Immunohistochemistry (IHC) (1)|
|Epitopes||1st Cytoplasmic Loop (1), Internal Region (1)|