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Details for Product No. ABIN351046

Transmembrane Channel-Like 2 (Tmc2) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms C20orf145, dJ686C3.3, CWEA2
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN351046
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for TMC2.
Purity whole serum
Alternative Name transmembrane channel-like protein 2 (TMC2)
Background Function: May be required for the normal function of cochlear hair cells.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Inner ear and testis.
Developmental stage: Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20. Also known as:transmembrane cochlear-expressed protein 2, TMC2.
UniProt Q8TDI7
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Kurima, Peters, Yang et al.: "Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function." in: Nature genetics, Vol. 30, Issue 3, pp. 277-84, 2002 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Alternatives for antigen "Transmembrane Channel-Like 2 (Tmc2)", type "Antibodies"
Hosts (5)
Reactivities (3), (2), (1), (1), (1)
Applications (5), (1), (1), (1), (1)
Epitopes (1), (1), (1)
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