Transmembrane Channel-Like 2 (Tmc2) (4th cytoplasmic loop) antibody

Antigen: Transmembrane Channel-Like 2 (Tmc2)

Synonyms: C20orf145, dJ686C3.3, CWEA2

Epitope: 4th cytoplasmic loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351046

Additional Information

Alternative name: transmembrane channel-like protein 2 (TMC2) (4th cytoplasmic loop)

Swiss-Prot: Q8TDI7

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May be required for the normal function of cochlear hair cells. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Inner ear and testis. DEVELOPMENTAL STAGE: Expressed at low, constant levels in temporal bone from embryonic day 14 to day 1 after birth. Increases by 8 to 16-fold at day 5, 10 and 20. Also known as:transmembrane cochlear-expressed protein 2, TMC2.

Specificity: Appears to be specific for TMC2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Kurima, Peters, Yang et al.: "Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function." in: Nature genetics, Vol. 30, Issue 3, pp. 277-84, 2002 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).